| 五元氮杂环阿魏酸衍生物的合成 |
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| 引用本文： | 许勤龙,李家明,王融融,周鹏,邬皓,袁明.五元氮杂环阿魏酸衍生物的合成[J].安徽化工,2011(5):19-23. |
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| 作者姓名： | 许勤龙 李家明 王融融 周鹏 邬皓 袁明 |
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| 作者单位： | 安徽中医学院药学院安徽省现代中药重点实验室; |
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| 基金项目： | 国家科技重大专项重大新药创制项目(批准号:2009ZX09103-123); 安徽省高校自然基金重点项目(批准号:KJ2010A206) |
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| 摘 要： | 目的：合成4个五元氮杂环阿魏酸衍生物。方法：以阿魏酸乙酯为起始原料,经Williamson醚化、亲核取代反应和水解反应,合成五元氮杂环阿魏酸衍生物。结果：所合成的目标化合物未见文献报道,目标化合物的结构经IR、1H-NMR、13C-NMR及MS确证。结论：所设计的合成技术简单易行。
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| 关 键 词： | 阿魏酸 抗血小板聚集 合成 |
Synthesis of Five-Membered Nitrogen-Containing Heterocycle Ferulic Acid Derivatives |
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| XU Qin-long,LI Jia-ming,WANG Rong-rong,ZHOU Peng,WU Hao,YUAN Ming.Synthesis of Five-Membered Nitrogen-Containing Heterocycle Ferulic Acid Derivatives[J].Anhui Chemical Industry,2011(5):19-23. |
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| Authors: | XU Qin-long LI Jia-ming WANG Rong-rong ZHOU Peng WU Hao YUAN Ming |
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| Affiliation: | XU Qin-long,LI Jia-ming,WANG Rong-rong,ZHOU Peng,WU Hao,YUAN Ming(Department of Pharmacy,Anhui University of Traditional Chinese Medicine,Anhui Key Laboratory of Traditional Chinese Medicine,Hefei 230031,China) |
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| Abstract: | Objective:To synthesize four five-membered Nitrogen-containing heterocycle ferulic acid derivatives.Methods:Ferulic acid ethyl ester,imidazole and triazole were used as starting material.The target compounds were synthesized from aryl esters via Willamson etherification,nucleophilic substitution,and hydroxylation.Results: The target compounds have not been reported.The chemical structures were confirmed by IR,1H-NMR,13C-NMR and MS.Conclusion: This synthetic technique is simple and feasible. |
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| Keywords: | ferulic acid platelet aggregation inhibitory synthesis |
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