Silica shell-assisted synthetic route for mono-disperse persistent nanophosphors with enhanced in vivo recharged near-infrared persistent luminescence |
| |
Authors: | Zou Rui Huang Junjian Shi Junpeng Huang Lin Zhang Xuejie Wong Ka-Leung Zhang Hongwu Jin Dayong Wang Jing Su Qiang |
| |
Affiliation: | 1. Key Lab of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China;2. Department of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China;3. Institute for Biomedical Materials and Devices(IBMD), Faculty of Science, University of Technology Sydney, NSW 2007, Australia |
| |
Abstract: | Near-infrared (NIR) persistent-luminescence nanoparticles have emerged as a new class of background-free contrast agents that are promising for in vivo imaging.The next key roadblock is to establish a robust and controllable method for synthesizing monodisperse nanoparticles with high luminescence brightness and long persistent duration.Herein,we report a synthesis strategy involving the coating/etching of the SiO2 shell to obtain a new class of small NIR highly persistent luminescent ZnGa2O4∶Cr3+,Sn4+ (ZGOCS) nanoparticles.The optimized ZGOCS nanoparticles have an excellent size distribution of ~15 nm without any agglomeration and an NIR persistent luminescence that is enhanced by a factor of 13.5,owing to the key role of the SiO2 shell in preventing nanoparticle agglomeration after annealing.The ZGOCS nanoparticles have a signal-to-noise ratio ~3 times higher than that of previously reported ZnGa2O4∶Cr3+ (ZGC-1) nanoparticles as an NIR persistent-luminescence probe for in vivo bioimaging.Moreover,the persistent-luminescence signal from the ZGOCS nanoparticles can be repeatedly re-charged in situ with external excitation by a white lightemitting diode;thus,the nanoparticles are suitable for long-term in vivo imaging applications.Our study suggests an improved strategy for fabricating novel high-performance optical nanoparticles with good biocompatibility. |
| |
Keywords: | core-shell structure in vivo imaging narrow size distribution near-infrared (NIR) persistent luminescence biocompatibility |
本文献已被 万方数据 SpringerLink 等数据库收录! |
|