美洛西林钠的合成

美洛西林钠是一种新型半合成青霉素。在以往的文献中其合成过程中都要使用剧毒品光气作为反应物。今以2-咪唑烷酮为起始原料，经甲磺酰化、酰化等四步反应，合成了酰脲类青霉素美洛西林钠。在合成过程中用氯甲酸三氯甲酯替代光气对其重要中间体l-氯甲酰基-3-甲磺酰基-2-咪唑烷酮的合成工艺进行了改进，不仅避免了使用光气，而且收率也从文献值70％提高到75％。

Synthesis of Mezlocillin Sodium

Mezlocillin sodium is a new kind of important semi-synthetic penicillin. In all literatures mentioned mezlocillin sodium synthesis process, phosgene, a very toxic gas is almost unavoidably used as a reactant. To avoid the use of phosgene, The mezlocillin sodium was synthesized from starting material imidazolidin-2-one via four steps such as sulfonylation, acidylation of 3-methylsulfonyl imidazolidin-2-one, dehydrochloride and dehydration et al. The synthesis technology for the key intermediate 3-methylsulfonyl imidazolidin-2-one-1-carbonyl chlorides was improved by using trichloromethyl chlorocarbonate to instead of phosgene, and its corresponding yield was also raised to 75% comparing with the 70% in the literature. The structures of all the intermediates and target product were determined by 1HNMR.