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| 联苯取代1，3，4-噁二唑-2-硫酮的合成与表征 | |
| 引用本文： | 宋志冬,刘平乐,李珺姊,向建南.联苯取代1，3，4-噁二唑-2-硫酮的合成与表征[J].精细化工中间体,2009,39(6):55-56,68. |
| 作者姓名： | 宋志冬 刘平乐 李珺姊 向建南 |
| 作者单位： | 1. 湘潭大学化工学院,湖南,湘潭,411105;中国石油化工股份有限公司催化剂长岭分公司,湖南,岳阳,414012 2. 湘潭大学化工学院,湖南,湘潭,411105 3. 湖南大学,化学化工学院,湖南,长沙,410082 |
| 摘 要： | 以不同的芳香酸为原料，经酯化、氨解、环化反应合成了一系列1，3，4-噁二唑（4a-4e）。4中的N—H键与2-氰基-4’-溴甲基联苯经缩合反应合成了具有多种潜在生物活性尚未见文献报道的标题化合物5a～5e。5的结构经1HNMR，IR和MS表征确认。 |
| 关 键 词： | 氨解 环化 1 3 4-噁二唑 2-氰基-4’-溴甲基联苯 |
Synthesis and Characterization of 1,3,4-Oxadiazole-2-thione Derivatives |
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| SONG Zhi-dong,LIU Ping-le,LI Jun-zi,XIANG Jian-nan.Synthesis and Characterization of 1,3,4-Oxadiazole-2-thione Derivatives[J].Fine Chemical Intermediates,2009,39(6):55-56,68. | |
| Authors: | SONG Zhi-dong LIU Ping-le LI Jun-zi XIANG Jian-nan |
| Affiliation: | SONG Zhi-don , LIU Ping-le , LI Jun-zi , XIANG Jian-nan (1. College of Chemical Engineering, Xiangtan University, Xiangtan 411105, China; 2. Changling Catalyst Company of China Petroleum and Chemical Corporation, Yueyang 414012, China; 3. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China) |
| Abstract: | A series of 1,3,4-oxadiazole-2-thione (4a~4e) derivatives were synthesized from aromatic acids via esterification, ammonilysis and cyclization. Reaction of 4 with 2 -cyano -4' -bromomethyl biphenyl gave novel compounds 5a~5e with potent bioactivities, which were never reported in the literatures. 5 were confirmed with 1H NMR, IR and MS. |
| Keywords: | ammonilysis cyclization 1 3 4-oxadiazole-2-thione 2-cyano-4'-bromomethyl biphenyl |
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