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重症肌无力患儿免疫状态及静注免疫球蛋白的疗效
引用本文:邢杰,姜桂英,张思瑾,关爱华,关键.重症肌无力患儿免疫状态及静注免疫球蛋白的疗效[J].粉末涂料与涂装,2001,14(1):62-63.
作者姓名:邢杰  姜桂英  张思瑾  关爱华  关键
作者单位:邢杰(白求恩医科大学第二临床学院长春130041)       姜桂英(白求恩医科大学第二临床学院长春130041)       张思瑾(白求恩医科大学第二临床学院长春130041)       关爱华(吉林省肿瘤医院)       关键(吉林省肿瘤医院)
基金项目:本研究为吉林省科委资助课题.
摘    要:目的观察重症肌无力(MG)患儿机体免疫状态,比较静脉注射免疫球蛋白(IVIg)与免疫调节疗法 对MG的疗效。方法对83例MG患儿分别于治疗前和缓解后,采用单项免疫扩散法检测血清免疫球蛋白(Ig),用 EIJSA法检测乙酸胆碱受体抗体(AchRab)和可溶性白细胞介素-2受体(SIL-2R),以24名健康儿童为对照组;并 对上述患儿中的68例采用免疫调节疗法,25例采用IVIg疗法。结果初发和复发的MG患儿IgG、AchRab、SIL-2R 明显高于对照组(P<0.001),缓解后与对照组差异无显著意义(P>0.05);IVIg治疗组和免疫调节治组疗缓解率均 为92%,复发率IVIg组为8%,免疫调节组为18%,两组比较差异有显著意义(P<0.05)。结论IgG、AchRab、SIL- 2R随MG的病情而变化,可作为预测MG病情的依据;IVIg疗法在降低复发率方面优于免疫调节疗法。

关 键 词:重症肌无力  免疫调节  静脉注射
修稿时间:2000年1月21日

Immune States of Children with Myasthenia Gravis and Curative Effect ofIntravenous Ig on Them
XING Jie,JIANG Guiying,ZHANG Sijin et al.Immune States of Children with Myasthenia Gravis and Curative Effect ofIntravenous Ig on Them[J].Chinese Journal of Biologicals,2001,14(1):62-63.
Authors:XING Jie  JIANG Guiying  ZHANG Sijin
Abstract:Objective To observe the immune states of children with myasthenia gravis(MG) and compare the curative effects of intravenous Ig(IVIg)and immunoregulatory therapy on them.Methods The serum immnumoglobulin of 83 children with MG were detected by single immunodiffusion test before treatment and after remission, using 24 healthy children as control.The anti-acetylcholine receptor antibody(AchRab) and soluble IL-2 receptor(SLT-2R)of them were detected by ELISA. Of the 83 children,63 were treated by immunoregulatory therapy, and the rest 25 were treated with IVIg.Results The Ig,AchRab and SIL-2R levels of the children with primary and recurrent MG were significantly higher than those of control(P<0.001). However, after remission, no significant difference was observed between them(P>0.05). Both the remission rates of the children treated by IVIg and immunoregulatory therapy were 92%, but the recurrence rates of them were 8% and 18% respectively(P < 0. 05). Conclusion The Ig,AchRab and SIL-2R levels were changed with patients' conditions, so they could be used for the prediction of the state of illness. Compared with immunoregulatory therapy, treatment with IVIg was more effective in reducing recurrence rate.
Keywords:Myasthenia gravis Immunoregulation IVIg
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