Hepatic veno-occlusive disease associated to the use of azathioprine in a renal transplant recipient |
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Authors: | K Hola J Brahm M Alvo A Cotera W Passalacqua G Smok |
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Affiliation: | Departamento de Medicina Interna, Hospital Clínico Universidad de Chile. |
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Abstract: | We report a 30 years old male, recipient of a kidney allograft and treated with azathioprine, who eighteen days after transplantation had a clinically asymptomatic elevation of total bilirubin and alkaline phosphatases. Nineteen months later, he presented with mild ascites, with a total bilirubin of 3.5 mg/dl, alkaline phosphatases of 308 U/L (normal < 170 U/L) and a prothrombin time at 55% of control. A liver biopsy showed sinusoidal and perivenular fibrosis without inflammation, compatible with chronic venous obstruction. Hepatic veno-occlusive disease is an infrequent complication of azathioprine use. |
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