Negative ion electrospray ionization tandem mass spectrometry in the structural characterization of penicillins |
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Authors: | S Rabbolini E Verardo M Da Col AM Gioacchini P Traldi |
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Affiliation: | RIBBON S.r.l., Milano, Italy. |
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Abstract: | The mass spectrometry (MS) behaviour of ten commercially available penicillins has been studied by means of electrospray and multiple-stage MS/MS experiments performed using an ion trap instrument. For all the examined compounds negative ions are produced under ESI conditions, with a yield two or three orders of magnitude higher than that observed for positive ions. MSn experiments indicate the occurrence of a fragmentation pathway related to the beta-lactam ring, different from that usually described for positive ions of these compounds, and provide structural information on both the beta-lactam ring and the side chains. |
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