Bacterial translocation and wasting in stressed mice |
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| Authors: | F García Tamayo LI Terrazas Valdés N Malpica López L Bonifáz Alfonso |
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| Affiliation: | Drug Serendipity Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd, Tokyo, Japan. |
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| Abstract: | The structures of YM-51084 and YM-51085, new protease inhibitors produced by Streptomyces sp. Q21705, were determined by 1H- and 13C-NMR and mass spectrometry. Both were characterized by the basic structures of an acyl-tripeptide. YM-51084 was elucidated to be isovaleryl-tyrosyl-valyl-phenylalaninal and YM-51085 was the reduced phenylalaninol form of YM-51084. These compounds proved to strongly inhibit human kidney cathepsin L; the IC50 values being 9.6 x 10(-9) M and 3.5 x 10(-7) M, respectively. |
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