Platelet-Derived Extracellular Vesicles for Regenerative Medicine |
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Authors: | Miquel Antich-Rosselló ,Maria Antò nia Forteza-Genestra,Marta Monjo,Joana M. Ramis |
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Affiliation: | 1.Cell Therapy and Tissue Engineering Group, Research Institute on Health Sciences (IUNICS), University of the Balearic Islands (UIB), Ctra. Valldemossa km 7.5, 07122 Palma, Spain; (M.A.-R.); (M.A.F.-G.);2.Health Research Institute of the Balearic Islands (IdISBa), 07120 Palma, Spain;3.Departament de Biologia Fonamental i Ciències de la Salut, University of the Balearic Islands (UIB), 07122 Palma, Spain |
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Abstract: | Extracellular vesicles (EVs) present a great potential for the development of new treatments in the biomedical field. To be used as therapeutics, many different sources have been used for EVs obtention, while only a few studies have addressed the use of platelet-derived EVs (pEVs). In fact, pEVs have been shown to intervene in different healing responses, thus some studies have evaluated their regenerative capability in wound healing or hemorrhagic shock. Even more, pEVs have proven to induce cellular differentiation, enhancing musculoskeletal or neural regeneration. However, the obtention and characterization of pEVs is widely heterogeneous and differs from the recommendations of the International Society for Extracellular Vesicles. Therefore, in this review, we aim to present the main advances in the therapeutical use of pEVs in the regenerative medicine field while highlighting the isolation and characterization steps followed. The main goal of this review is to portray the studies performed in order to enhance the translation of the pEVs research into feasible therapeutical applications. |
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Keywords: | extracellular vesicles exosomes platelets regenerative medicine |
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