Nanotechnology-Based Strategies to Overcome Current Barriers in Gene Delivery |
| |
| Authors: | Sofí a Miró n-Barroso,Elena B. Domè nech,Sonia Trigueros |
| |
| Affiliation: | 1.Institute of Molecular Biology of Barcelona, IBMB-CSIC, 08028 Barcelona, Spain;2.Department of Genetics Microbiology and Statistics, University of Barcelona, 08007 Barcelona, Spain;3.Department of Zoology, University of Oxford, Oxford OX1 3PS, UK |
| |
| Abstract: | Nanomaterials are currently being developed for the specific cell/tissue/organ delivery of genetic material. Nanomaterials are considered as non-viral vectors for gene therapy use. However, there are several requirements for developing a device small enough to become an efficient gene-delivery tool. Considering that the non-viral vectors tested so far show very low efficiency of gene delivery, there is a need to develop nanotechnology-based strategies to overcome current barriers in gene delivery. Selected nanostructures can incorporate several genetic materials, such as plasmid DNA, mRNA, and siRNA. In the field of nanotechnologies, there are still some limitations yet to be resolved for their use as gene delivery systems, such as potential toxicity and low transfection efficiency. Undeniably, novel properties at the nanoscale are essential to overcome these limitations. In this paper, we will explore the latest advances in nanotechnology in the gene delivery field. |
| |
| Keywords: | nanotechnology nanomaterials nanomedicine delivery gene therapy genetic material gene therapeutics biological barriers cancer |
|
|
