|
|||||
|
|
Clearance of the SARS-CoV-2 Virus in an Immunocompromised Patient Mediated by Convalescent Plasma without B-Cell Recovery |
|
| Authors: | Maamoun Basheer Elias Saad Orly Laskar Ofir Schuster Hagai Rechnitzer Simona Zisman-Rozen David Azoulay Nimer Assy |
| Affiliation: | 1.Internal Medicine Department, Galilee Medical Center, Nahariya 2210001, Israel;2.Azrieli Bar-Ilan Faculty of Medicine, Safad 2210001, Israel;3.Department of Infectious Diseases, Israel Institute for Biological Research, Ness Ziona 7404905, Israel; (O.L.); (O.S.);4.The Clinical Microbiology Laboratory, Galilee Medical Center, Nahariya 2210001, Israel; (H.R.); (S.Z.-R.);5.Hematology Unit and Clinical Laboratory, Galilee Medical Center, Nahariya 2210001, Israel |
| Abstract: | Coronavirus disease (COVID-19) is a contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This case report presents a patient who had difficulty eradicating the corona virus due to being treated with Rituximab, which depletes B lymphocyte cells and therefore disables the production of neutralizing antibodies. The combined use of external anti-viral agents like convalescent plasma, IVIG and Remdesivir successfully helped the patient’s immune system to eradicate the virus without B-cell population recovery. In vitro studies showed that convalescent plasma is the main agent that helped in eradicating the virus. |
| Keywords: | immunocompromised SARS-COV-2 pneumonia T lymphocytes |