| 苄青霉素盐结晶过程 |
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| 引用本文： | 王静康,张美景,万涛,平志存,韩贵安. 苄青霉素盐结晶过程[J]. 化工学报, 1996, 47(1): 100 |
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| 作者姓名： | 王静康 张美景 万涛 平志存 韩贵安 |
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| 作者单位： | 天津大学化工系!天津300072,天津大学化工系!天津300072,天津大学化工系!天津300072,华北制药厂!石家庄050011,华北制药厂!石家庄050011 |
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| 摘 要： | 本文研究了β-内酰胺类抗菌素药物真空闪蒸结晶过程．以苄青霉素钾盐为例，测定了该物系的结晶热力学相图与介稳区曲线，应用间歇动态法确定了该物系的结晶动力学参数，进而求取了最佳操作时间表.
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| 关 键 词： | 苄青霉素盐 真空蒸发 结晶介稳区 结晶动力学 |
THE CRYSTALLIZATION PROCESS FOR PENICILLIN G SALT |
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| Wang Jingkang,Zhang Mening,Wan Tao,Ping Zhicun,Han guian（Chemical Engineering Department,Tianjin University,Tianjin ）（Pharmacy Company of North Chian,Shijiazhuang ）. THE CRYSTALLIZATION PROCESS FOR PENICILLIN G SALT[J]. Journal of Chemical Industry and Engineering(China), 1996, 47(1): 100 |
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| Authors: | Wang Jingkang Zhang Mening Wan Tao Ping Zhicun Han guian（Chemical Engineering Department Tianjin University Tianjin ）（Pharmacy Company of North Chian Shijiazhuang ） |
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| Abstract: | In this paper,the vacuum evaporative crystallization process of β lactam antimicrobial pharmaceuticals is studied.The crystallization thermodynamic data,such as the phase equilibrium diagram and the metastable zone of pencillin G potassium are determined.Furthermore,the crystallization kinetic parameters for penicillin G potassium salt in n-butanolwater solution are measured by using an unsteady method.Therefore,the optimal operating time table for the crystallization process is established. |
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| Keywords: | penicillin G salt vacuum evaporation metastable zone crystallization kinetics |
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