| 8-碘-9-苄基-9H-嘌呤的合成 |
| |
| 引用本文： | 刘福胜,于世涛,解从霞,葛晓萍.8-碘-9-苄基-9H-嘌呤的合成[J].精细化工,2004,21(11):837-839. |
| |
| 作者姓名： | 刘福胜 于世涛 解从霞 葛晓萍 |
| |
| 作者单位： | 青岛科技大学,化工学院,山东,青岛,266042 |
| |
| 基金项目： | 山东省优秀中青年科学家科研奖励基金资助(02BS107)~~ |
| |
| 摘 要： | 以9 苄基 9H 嘌呤和碘代丁二酰亚胺(NIS)等为主要原料,以THF为溶剂,对8 碘 9 苄基 9H 嘌呤的合成反应进行了研究。对主要反应条件的影响结果进行了考察,在反应温度70℃,n(9 苄基 9H 嘌呤)∶n(碘代丁二酰亚胺)=1 0∶2 5,反应时间48h的较佳条件下,产物收率>87%。用1HNMR、13CNMR、MS、碳氢相关谱(HETCOR)和远程碳氢相关谱(LongRangeHETCOR)等技术对产物结构进行了表征。
|
| 关 键 词： | 8碘9苄基9H嘌呤 9苄基9H嘌呤 碘代丁二酰亚胺 |
| 文章编号： | 1003-5214(2004)011-0837-03 |
Synthesis of 8-Iodo-9-benzyl-9H-purine |
| |
| LIU Fu-sheng,YU Shi-tao,XIE Cong-xia,GE Xiao-ping.Synthesis of 8-Iodo-9-benzyl-9H-purine[J].Fine Chemicals,2004,21(11):837-839. |
| |
| Authors: | LIU Fu-sheng YU Shi-tao XIE Cong-xia GE Xiao-ping |
| |
| Abstract: | 8-Iodo-9-benzyl-9H-purine was synthesized using 9-benzyl-9H-purine(Ⅰ) and N-iodosuccinimide(Ⅱ) as starting materials and tetrahydrofuran as solvent.Under the optimum reaction conditions of reaction temperature 70 ℃,n(Ⅰ)∶n(Ⅱ)=1.0∶2.5 and reaction time 48 h,yield of the product was over 87%.The product was characterized by~1HNMR,~(13)CNMR,MS,Heteronuclear correlation(HETCOR) and long range HETCOR. |
| |
| Keywords: | 8-iodo-9-benzyl-9H-purine 9-benzyl-9H-purine N-iodosuccinimide |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
