Acylglycerol structure of genetic varieties of peanut oils of varying atherogenic potential |
| |
Authors: | F Manganaro J J Myher A Kuksis D Kritchevsky |
| |
Affiliation: | (1) Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada;(2) The Wistar Institute of Anatomy and Biology, Philadelphia, PA |
| |
Abstract: | Detailed investigation was made of the triacylglycerol structure of three varieties of peanut oils of varying atherogenic
activity. By means of chromatographic and stereospecific analyses, it was shown that all the oils had markedly nonrandom enantiomeric
structures with the long chain saturated fatty acids (C20−C24) confined exclusively to thesn-3-position, whereas the palmitic and oleic acids were distributed about equally between thesn-1-andsn-3-positions, with the linoleic acid being found preferentially in thesn-2-position. On the basis of detailed studies of the molecular species of the separatesn-1,2-,sn-2,3- andsn-1,3-diacylglycerol moieties, it was concluded that the fatty acids in the three positions of the glycerol molecule are combined
with each other solely on the basis of their relative molar concentrations. As a result, it was possible to calculate the
composition of the molecular species of the peanut oil triacylglycerols (including the content of the enantiomers and the
reverse isomers) by means of the 1-random 2-random 3-random distribution. In general, the three peanut oils possessed triacylglycerol
structures which where closely similar to that derived earlier for a commercial peanut oil of North American origin. Since
their oil has exhibited a high degree of atherogenic potential, it was anticipated that the present oils would likewise be
atherogenic, which has been confirmed by biological testing. However, there are certain differences in the triacylglycerol
structures among these oils, which can be correlated with the variations in their atherogenic activity. The major differences
reside in the linoleic/oleic acid ratios in the triacylglycerols, especially in thesn-2-position, and in the proportions in which these acids are combined with the long chain fatty acids. On the basis of the
characteristic structures identified in the earlier analyzed atherogenic peanut oil, the peanut oil of South American origin
would be judged to possess the greatest atherogenic potential and this has been borne out by biological testing. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|