Photoreactive analog of peptide FN-C/H-V from the carboxy-terminal heparin-binding domains of fibronectin supports endothelial cell adhesion and spreading on biomaterial surfaces |
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Authors: | JB Huebsch GB Fields TG Triebes DL Mooradian |
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Affiliation: | Cardiac Arrhythmia Service, New England Medical Center Hospitals, Tufts University School of Medicine, Boston, Massachusetts, USA. |
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Abstract: | RF catheter ablation is a safe and extremely effective method of achieving complete A-V block in patients with difficult-to-control ventricular rates in atrial fibrillation. In selected patients, A-V junction ablation may improve exercise capacity and functional status while reducing the need for emergency care and hospitalization. Prospective, randomized studies are needed, however, to compare A-V junction ablation as a management strategy to pharmacologic therapy to control ventricular rate or to maintain sinus rhythm. Similarly, additional data are needed to assess methods of achieving A-V junction modification with the lowest risk for A-V block. |
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