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Synthesis and Drug‐Delivery Behavior of Chitosan‐Functionalized Graphene Oxide Hybrid Nanosheets |
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| Authors: | Vijay Kumar Rana Myeon‐Cheon Choi Jin‐Yeon Kong Gwang Yeon Kim Mi Ju Kim Sun‐Hee Kim Satyendra Mishra Raj Pal Singh Chang‐Sik Ha |
| Affiliation: | 1. Department of Polymer Science and Engineering, Pusan National University, Geumjeong‐gu, Busan 609‐735, Korea;2. Department of Biochemistry, School of Medicine, Pusan National University, Yangsan 626‐870, South Korea;3. Department of Chemical Technology, North Maharastra University, Jalgaon 425001, India;4. Division of Polymer Science and Engineering, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India |
| Abstract: | Chitosan‐functionalized graphene oxides (FGOCs) were successfully synthesized. FGOCs were found to significantly improve the solubility of the GO in aqueous acidic media. The presence of organic groups was confirmed by means of XPS and TGA. Restoration of the sp2 carbon network and exfoliation of graphene sheets were confirmed by Raman spectroscopy, UV‐visible spectroscopy and WAXD. The SEM and AFM investigations of the resultant FGOCs showed that most of the graphene sheets were individual and few were layered. Controlled release behavior of Ibuprofen and 5‐fluorouracil was then investigated. We found that FGOCs are a promising new material for biological and medical applications.  |
| Keywords: | biocompatibility chitosan drug delivery systems functionalization of polymers solution properties |