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| Witting-Horner反应合成3-甲基-5-（2,6,6-三甲基-1-环己烯-1-基）-2,4-戊二烯基膦酸二烷基酯 | |
| 引用本文： | 虞国棋,谈金辉,潘伯安,陈钧,舒丽东,杨学英,李良军.Witting-Horner反应合成3-甲基-5-（2,6,6-三甲基-1-环己烯-1-基）-2,4-戊二烯基膦酸二烷基酯[J].云南化工,2010,37(1):32-36. |
| 作者姓名： | 虞国棋 谈金辉 潘伯安 陈钧 舒丽东 杨学英 李良军 |
| 作者单位： | 1. 浙江医药股份有限公司维生素厂,浙江,绍兴,312000 2. 湖州出入境检验检疫局,浙江,湖州,313000 3. 浙江国邦药业有限公司,浙江,绍兴,312369 |
| 摘 要： | 3-甲基-5-（2,6,6-三甲基-1-环己烯-1-基）-2,4-戊二烯基膦酸二烷基酯是维生素A的中间体。β-紫罗兰酮与乙二膦酸四乙酯在碱催化下进行Witting-Horner缩合反应得到目标化合物,其含量为90.5%,收率46.1%。 |
| 关 键 词： | 3-甲基-5-（2 6 6-三甲基-1-环己烯-1-基）-2 4-戊二烯基膦酸二烷基酯 β-紫罗兰酮 乙二膦酸四乙酯 Witting-Horner缩合反应 维生素A |
Synthesis of 3-Methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl phosphonate by Witting-Horner Reaction |
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| YU Guo-qi,TAN Jin-hui,PAN Bo-an,CHEN Jun,SHU Li-dong,YANG Xue-ying,LI Liang-jun.Synthesis of 3-Methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl phosphonate by Witting-Horner Reaction[J].Yunnan Chemical Technology,2010,37(1):32-36. | |
| Authors: | YU Guo-qi TAN Jin-hui PAN Bo-an CHEN Jun SHU Li-dong YANG Xue-ying LI Liang-jun |
| Affiliation: | 1.Zhejiang Medicine Co.Ltd.,Vitamin Factory,Shaoxing 312071,China;2.Hu Zhou Entry-Exit Inspection and Quarantine Bureau,Huzhou 313000,China;3.Zhejiang Guobang Pharmaceutical Co.,Ltd.,Shaoxing 312369,China) |
| Abstract: | β-Ionone and 1,2-Bisphosphonate-ethane undergo Witting-Horner reaction in the presence of base to prepare-3-methyl-5-（2,6,6-trimethyl-1-cyclohexen-1-yl）-2,4-pentadienyl phosphonate,which is an important intermediate of Retinol acetate.Purity of the product is 90.5% and yield is 46.1%. |
| Keywords: | 3-Methyl-5-（2 6 6-trimethyl-1-cyclohexen-1-yl）-2 4-pentadienyl phosphonates β-ionone 1 2-bisphosphonate-ethane Witting-Horner reaction vitamine A |
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