| 3，4，5－三甲氧基苯甲醛合成工艺改进 |
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| 引用本文： | 杭超,刘国智. 3，4，5－三甲氧基苯甲醛合成工艺改进[J]. 陶瓷科学与艺术, 1996, 0(4) |
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| 作者姓名： | 杭超 刘国智 |
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| 作者单位： | 南京化工大学化学工程系 |
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| 摘 要： | 羟基苯甲醛在氧化剂存在下溴化生成３，５－二溴－４－羟基苯甲醛，后者用氯化亚铜作催化剂，在ＤＭＦ溶剂中与甲醇钠反应，生成丁香醛。丁香醛在ｐＨ９～１０之间用硫酸二甲酯甲基化得到医药中间体３，４，５－三甲氧基苯甲醛。对各步反应工艺条件进行了探讨。整个工艺路线简便，总收率达７０％。
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| 关 键 词： | 3，4，5－三甲氧基苯甲醛 合成 甲氧基化 甲基化 |
REVISED METHOD FOR PREPARATION OF 3,4,5 TRIMETHOXYBENZALDEHYDE |
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| Hang Chao Liu Guozhi. REVISED METHOD FOR PREPARATION OF 3,4,5 TRIMETHOXYBENZALDEHYDE[J]. Ceramics Science & Art, 1996, 0(4) |
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| Authors: | Hang Chao Liu Guozhi |
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| Affiliation: | Hang Chao Liu Guozhi Department of Chemical Engineering,Nanjing University of Chemical Technology,Nanjing,China,210009 |
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| Abstract: | Hydroxybenzaldehyde was brominated in the presence of sodium chlorate to 3,5 dibromo 4 hydroxybenzaldehyde, which reacted with sodium methoxide in the presence of cuprous chloride to give syringaldehyde. THe latter was methylated to give 3,4,5 trimethoxybenzaldehyde(TMB). The reaction conditions were studied. |
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| Keywords: | trimethoxybenzaldehyde synthesis methoxylation methylation |
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