Early response monitoring in malignant lymphoma using fluorine-18 fluorodeoxyglucose single-photon emission tomography |
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Authors: | OS Hoekstra A van Lingen GJ Ossenkoppele R Golding GJ Teule |
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Affiliation: | Department of Nuclear Medicine, Free University Hospital, Amsterdam, The Netherlands. |
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Abstract: | Metabolic response monitoring early during chemotherapy may have a major impact on clinical management of patients with malignant lymphoma. In two patients with non-Hodgkin's lymphoma fluorine-18 fluorodeoxyglucose (18FDG) single-photon emission tomography (SPET) studies were performed during the first two chemotherapeutic cycles. Persisting uptake predicted treatment failure whereas a sharp reduction of 18FDG uptake was demonstrated in the case of a responsive tumour. Qualitative analysis of conventional 18FDG imaging may thus serve to identify patients with a non-responding tumour. The potential of this technique in the determination of the initial response remains to be established. Imaging with 18FDG and SPET appears promising as a more easily available methodology than 18FDG positron emission tomography. |
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