| 美伐他汀二次精制母液回收的研究 |
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| 引用本文： | 黄扬文,张起智,郑滔. 美伐他汀二次精制母液回收的研究[J]. 广州化工, 2012, 40(6): 63-64,86 |
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| 作者姓名： | 黄扬文 张起智 郑滔 |
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| 作者单位： | 丽珠集团新北江制药股份有限公司,广东清远,511515 |
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| 摘 要： | 对美伐他汀（Mevastatin）二次精制母液进行回收工艺的研究,确定了美伐他汀二次精制母液进行浓缩结晶,所得湿粉再用20倍体积的甲苯溶解后,加入0.2倍体积2%NaHCO3溶液洗涤,甲苯相再浓缩结晶的回收工艺,以HPLC检测方法测定回收品含量为70%,美伐他汀母液平均回收率为60%。该工艺具有简单可靠,收率较高、成本较低的特点。
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| 关 键 词： | 美伐他汀 母液回收 结晶 碱洗 |
Recovery Process of Mevastatin from Secondary Refined Mother Liquor |
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| HUANG Yang-wen,ZHANG Qi-zhi,ZHENG Tao. Recovery Process of Mevastatin from Secondary Refined Mother Liquor[J]. GuangZhou Chemical Industry and Technology, 2012, 40(6): 63-64,86 |
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| Authors: | HUANG Yang-wen ZHANG Qi-zhi ZHENG Tao |
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| Affiliation: | (Livzon New North River Pharmaceutical Co.,Ltd.,Guangdong Qingyuan 511515,China) |
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| Abstract: | The recovery process of Mevastatin from secondary refined mother liquor was studied.After concentration and crystallization,the Mevastatin of secondary refined mother liquor was dissolved in toluene which was 20 times volume of the Mevastatin,then 0.2 times volume of 2% sodium bicarbonate solution was added to washing the toluene phase.The product was obtained after concentration and crystallization.The average recovery rate was 60% and content was 70%.The recovery process was simple,cheaper and with higher recovery. |
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| Keywords: | Mevastatin secondary recovery crystallization alkali washing |
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