Corneal swelling caused by conventional and new-design low-Dk soft contact lenses following a 10-day daily wear trial regime |
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| Affiliation: | 1. Department of Ophthalmology and Visual Science, Daejeon St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;2. Department of Ophthalmology and Visual Science, Seoul St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;3. Department of Ophthalmology and Visual Science, Uijeongbu St. Mary''s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea;1. Retina Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran;2. Refractive Error Research Centre, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Optometry, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran;4. Computer Engineering Department, Faculty of Engineering, Ferdowsi University of Mashhad, Mashhad, Iran;5. Department of Social Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;1. Key Laboratory of Polymer Functional Materials, College of Chemical Engineering and Material, Heilongjiang University, Harbin 150080, PR China;2. Key Laboratory of Functional Inorganic Material Chemistry, School of Chemical Engineering and Material, Heilongjiang University, Ministry of Education, Harbin 150080, PR China;3. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Changchun 130022, PR China |
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| Abstract: | PurposeTo investigate the efficacy and safety of a fenestrated and channelled soft contact lens (F-SCL) compared to a standard and non-fenestrated soft contact lens (S-SCL) in experienced soft contact lens (SCL) wearers.MethodsThis was a randomised, crossover, single-blinded (subject), and multicentre clinical trial. Sixteen experienced SCL wearers were randomly divided into two groups (FS and SF). The FS group first wore F-SCLs followed by S-SCLs, each for 10 days, separated by a 1-week washout period, whereas the SF group wore the S-SCLs first and crossed over to F-SCLs in the same manner. The F-SCLs were designed with three equally spaced, symmetrical fenestrations and a partial-thickness, connecting, circumferential channel on the back surface of the mid-periphery of the lens. Measurement of central corneal thickness using ultrasonic pachymetry was performed on the day of screening, after the 1-week washout period, and after 10 days of wearing each kind of lens, based on which central corneal swelling was calculated and compared. One eye in each subject was chosen at random for analysis.ResultsCentral corneal swelling was 1.92 ± 1.73% vs. 5.26 ± 2.14% in F-SCLs vs. S-SCLs wearers, which was statistically significant (P < 0.001). There was no significant difference between the groups in terms of SCL-corrected visual acuity or SCL-related adverse events.ConclusionThe use of F-SCLs led to reduced corneal swelling compared to S-SCLs. The newly incorporated features appear to improve tear mixing and thereby the oxygen supply to the cornea, which results in reduced corneal oedema. |
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| Keywords: | Contact lens Fenestration Channel Central corneal swelling ratio Central corneal thickness |
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