| 红霉素在丙酮溶液中的降解动力学研究 |
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| 引用本文： | 刘书妤,朱家文.红霉素在丙酮溶液中的降解动力学研究[J].化学世界,2013,54(1):12-13,17. |
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| 作者姓名： | 刘书妤 朱家文 |
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| 作者单位： | 1. 上海工程技术大学化学化工学院,上海,201620
2. 华东理工大学化学工程研究所,上海,200237 |
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| 摘 要： | 采用HPLC法测定红霉素药物浓度,研究红霉素在pH为7、8、9和10的条件下降解以及在15、25、35、45和55℃的条件下降解。不同pH缓冲溶液中,红霉素含量下降速度依次为pH 10>9>8>7,红霉素在pH 8和pH 9缓冲溶液中降解的反应速率常数分别为0.034h-1和0.0685h-1。不同温度条件下,红霉素含量下降速度依次为55>45>35>25>15℃,红霉素在15、25和35℃条件下,pH 10的缓冲溶液中降解的反应速率常数分别为0.2454h-1、0.3407h-1和0.4369h-1。
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| 关 键 词： | 红霉素 降解 动力学 |
Degradation Kinetics of Erythromycin in Acetone Solution |
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| LIU Shu-yu,ZHU Jia-wen.Degradation Kinetics of Erythromycin in Acetone Solution[J].Chemical World,2013,54(1):12-13,17. |
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| Authors: | LIU Shu-yu ZHU Jia-wen |
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| Affiliation: | 1.School of Chemistry and Chemical Engineering,Shanghai University of Engineering Science,Shanghai 201620,China; 2.Chemical Engineering Research Centre,East China University of Science and Technology,Shanghai 200237,China) |
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| Abstract: | HPLC method was used for the determination of erythromycin.The degradation of erythromycin was studied at pH=7,8,9 and 10 and at 15,25,35,45 and 55℃,respectively.Experimental results showed that the rate of decline of erythromycin followed by pH 10>9>8>7 in different pH buffer solutions.The rate constants were 0.034 h-1 and 0.0685 h-1 at pH 8 and pH 9,respectively.Under different temperatures,the rate of decline of erythromycin followed by 55>45>35>25>15℃.Experimental results showed that the rate constants were 0.2454 h-1,0.3407 h-1 and 0.4369 h-1 in solution(pH 10) at 15,25 and 35℃,respectively. |
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| Keywords: | erythromycin degradation kinetics |
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