Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy |
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| Authors: | Wansong Chen Jiang Ouyang Xinyao Yi Yan Xu Chengcheng Niu Weiyu Zhang Liqiang Wang Jianping Sheng Liu Deng You‐Nian Liu Shaojun Guo |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, China;2. State Key Laboratory for Powder Metallurgy, Central South University, Changsha, Hunan, China;3. Department of Ultrasound Diagnosis, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China;4. Department of Materials Science and Engineering, and BIC‐ESAT, College of Engineering, Peking University, Beijing, China |
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| Abstract: | Transition‐metal dyshomeostasis is recognized as a critical pathogenic factor at the onset and progression of neurodegenerative disorder (ND). Excess transition‐metal ions such as Cu2+ can catalyze the generation of cytotoxic reactive oxygen species and thereafter induce neuronal cell apoptosis. Exploring new chelating agents, which are not only capable of capturing excess redox‐active metal, but can also cross the blood–brain barrier (BBB), are highly desired for ND therapy. Herein, it is demonstrated that 2D black phosphorus (BP) nanosheets can capture Cu2+ efficiently and selectively to protect neuronal cells from Cu2+‐induced neurotoxicity. Moreover, both in vitro and in vivo studies show that the BBB permeability of BP nanosheets is significantly improved under near‐infrared laser irradiation due to their strong photothermal effect, which overcomes the drawback of conventional chelating agents. Furthermore, the excellent biocompatibility and stability guarantee the biosafety of BP in future clinical applications. Therefore, these features make BP nanosheets have the great potential to work as an efficient neuroprotective nanodrug for ND therapy. |
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| Keywords: | antioxidants black phosphorus nanosheets blood– brain barrier drug discovery neurodegenerative disorder |
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