不同剂量苹果膳食纤维对小鼠高血糖和高血脂的影响

为研究不同剂量苹果膳食纤维对糖尿病小鼠血糖水平和高脂饮食小鼠血脂水平的影响，以ICR小鼠为实验动物，分别给糖尿病模型和高脂饮食小鼠饲料中添加4%、2%、1%剂量苹果膳食纤维，另设对照组；喂养结束后分别测定其空腹血糖和血脂水平。结果显示：1%～4%剂量苹果膳食纤维不能降低糖尿病小鼠血糖值，但4%剂量可以抑制其血糖值显著升高。4%剂量苹果膳食纤维可有效降低高脂饮食小鼠血清胆固醇(TC)含量和动脉硬化指数(AI)，但不能恢复至正常水平；对血清甘油三酯(TG)含量可有效降低至接近正常水平；而较低剂量未发现有效作用。结论：苹果膳食纤维对小鼠的辅助降血糖和降血脂作用，当饲料中添加剂量达到4%时，才会有显著效果，较低剂量作用不显著。

Effect of Different Doses of Apple Dietary Fiber on Blood Glucose in Diabetic Mice and Blood Lipid in Hyperlipidic Mice

In order to explore the effect of apple dietary fiber on blood glucose level in diabetic mice and blood lipid level in hyperlipidic mice, apple dietary fiber at 4%, 2% and 1% doses was added to a basal diet for ICR mice with diabetes and to a high-fat diet for normal ICR mice, respectively. In the hypoglycemic evaluation of apple dietary fiber, ICR mice with diabetes fed the basal diet without added apple dietary fiber served as a model control group. The normal control and model control groups used for the hypolipidemic evaluation were given the basal diet and high-fat diet, respectively. Blood glucose and blood lipid of all the mice were determined at the end of the hypoglycemic and hypolipidemic treatments. The results indicated that the blood glucose level of the diabetic mice administered with apple dietary fiber at low doses did not exhibit an obvious decrease; however, the blood glucose was obviously inhibited in the mice administered with apple dietary fiber at the dose of 4% compared to the model control group. Meanwhile, apple dietary fiber at the dose of 4% also could effectively decrease serum total cholesterol (TC) and atherosclerosis index (AI) although it is difficult to decrease to normal level. On the other hand, apple dietary fiber at the high dose could result in the reduction of serum triglyceride to the normal level. Conclusion: Apple dietary fiber at the high dose level of 4% can reduce the blood glucose and blood lipid, but it does not reveal an obvious effect at the low dose level.