Development of core-shell microcapsules by a novel supercritical CO2 process |
| |
Authors: | Ai-Zheng Chen Yi Li Dong Chen Jun-Yan Hu |
| |
Affiliation: | (1) Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China |
| |
Abstract: | 5-fluorouracil-SiO2-poly(L-lactide) (5-Fu-SiO2-PLLA) microcapsules were prepared in a novel process of solution-enhanced dispersion by supercritical CO2 (SEDS). The SiO2 nanoparticles were loaded with 5-Fu by adsorption at the first place, then the 5-Fu-SiO2 nanoparticles were coated with PLLA by a modified SEDS process. The resulted microcapsules were characterized by scanning
electron microscope (SEM), laser diffraction particle size analyzer, Fourier transform infrared spectrometer (FTIR) and thermogravimeter-differential
scanning calorimeter (TG-DSC). The drug load, encapsulation efficiency and drug release profiles were also determined. The
resulted microcapsules exhibited a rather spherical shape, smooth surface, and a narrow particle size distribution with a
mean particle size of 536 nm. The drug load and encapsulation efficiency of the samples were 0.18% and 80.53%, respectively,
25.05% of 5-Fu was released in the first half hour, then drug released in a sustained process, which was much slower than
that of without coated by PLLA. The results indicated that the modified SEDS process could be used to produce drug-polymer
microcapsules with a core-shell structure, high encapsulation efficiency and sustained drug release effect. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|