Understanding the Interactions of Guanine Quadruplexes with Peptides as Novel Strategies for Diagnosis or Tuning Biological Functions |
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Authors: | Dr Tom Miclot Aurane Froux Luisa D'Anna Dr Emmanuelle Bignon Prof?Dr Stéphanie Grandemange Prof?Dr Giampaolo Barone Prof?Dr Antonio Monari Prof?Dr Alessio Terenzi |
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Affiliation: | 1. Universita di Palermo, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies Viale delle Scienze, 90128 Palermo, Italy;2. Université de Lorraine and CNRS, UMR 7019 LPCT, 54000 Nancy, France;3. Université de Lorraine and CNRS, UMR 7039 CRAN, 54000 Nancy, France;4. Université Paris Cité and CNRS, ITODYS, 75006 Paris, France |
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Abstract: | Guanine quadruplexes (G4s) are nucleic acid structures exhibiting a complex structural behavior and exerting crucial biological functions in both cells and viruses. The specific interactions of peptides with G4s, as well as an understanding of the factors driving the specific recognition are important for the rational design of both therapeutic and diagnostic agents. In this review, we examine the most important studies dealing with the interactions between G4s and peptides, highlighting the strengths and limitations of current analytic approaches. We also show how the combined use of high-level molecular simulation techniques and experimental spectroscopy is the best avenue to design specifically tuned and selective peptides, thus leading to the control of important biological functions. |
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Keywords: | DNA guanine quadruplexes molecular modeling peptides RNA spectroscopy |
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