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Phospholipid-Coated Boronic Oxide Nanoparticles as Boron Agents for Boron Neutron Capture Therapy |
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| Authors: | Dr. Riku Kawasaki Hidetoshi Hirano Keita Yamana Ayano Oshige Kotaro Nishimura Nanami Kono Dr. Yu Sanada Kaori Bando Anri Tabata Naoki Yasukawa Dr. Hideki Azuma Takushi Takata Dr. Yoshinori Sakurai Prof. Hiroki Tanaka Prof. Minoru Suzuki Dr. Naoki Tarutani Prof. Kiyofumi Katagiri Prof. Takeshi Nagasaki Prof. Atsushi Ikeda |
| Affiliation: | 1. Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527 Higashi-Hiroshima, Japan;2. Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527 Higashi-Hiroshima, Japan These authors contributed equally to this work. Contribution: Data curation (lead), Investigation (lead), Methodology (lead), Writing - original draft (lead), Writing - review & editing (lead);3. Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527 Higashi-Hiroshima, Japan These authors contributed equally to this work. Contribution: Formal analysis (lead), Investigation (lead), Methodology (lead);4. Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527 Higashi-Hiroshima, Japan Contribution: Investigation (equal), Methodology (equal);5. Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527 Higashi-Hiroshima, Japan Contribution: Investigation (supporting);6. Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527 Higashi-Hiroshima, Japan Contribution: Investigation (supporting), Methodology (supporting);7. Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494 Sennan-gun, Osaka, Japan Contribution: Conceptualization (lead);8. Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585 Osaka city, Japan Contribution: Data curation (supporting), Investigation (supporting);9. Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585 Osaka city, Japan Contribution: Investigation (supporting), Methodology (supporting);10. Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585 Osaka city, Japan Contribution: Data curation (equal);11. Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494 Sennan-gun, Osaka, Japan Contribution: Data curation (equal), Formal analysis (equal);12. Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494 Sennan-gun, Osaka, Japan Contribution: Data curation (equal);13. Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494 Sennan-gun, Osaka, Japan Contribution: Formal analysis (equal);14. Institute for Integrated Radiation and Nuclear Science, Kyoto University, Asashiro-Nishi, Kumatori-cho, 590-0494 Sennan-gun, Osaka, Japan Contribution: Investigation (equal), Methodology (equal), Resources (equal);15. Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, 739-8527 Higashi-Hiroshima, Japan Contribution: Data curation (supporting), Investigation (supporting);16. Department of Chemistry and Bioengineering Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585 Osaka city, Japan Contribution: Funding acquisition (equal), Investigation (lead), Project administration (lead) |
| Abstract: | Minimally invasive boron neutron capture therapy (BNCT) is an elegant approach for cancer treatment. The highly selective and efficient deliverability of boron agents to cancer cells is the key to maximizing the therapeutic benefits of BNCT. In addition, enhancement of the frequencies to achieve boron neutron capture reaction is also significant in improving therapeutic efficacy by providing a highly concentrated boron agent in each boron nanoparticle. As the density of the thermal neutron beam remains low, it is unable to induce high-efficiency cell destruction. Herein, we report phospholipid-coated boronic oxide nanoparticles as agents for BNCT that can provide a highly concentrated boron atom in each nanoparticle. The current system exhibited in vitro BNCT activity seven times higher than that of commercial boron agents. Furthermore, the system could penetrate cancer spheroids deeply, efficiently suppressing thermal neutron irradiation-induced growth. |
| Keywords: | boron neutron capture therapy drug delivery systems lipid nanoparticles organic–inorganic hybrid nanomaterials |