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Type II Polyketide Synthases: A Bioinformatics-Driven Approach |
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| Authors: | Shengling Xie Prof?Dr Lihan Zhang |
| Affiliation: | 1. Department of Chemistry, Zhejiang University, Hangzhou, 310058 Zhejiang Province, China
Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science, Westlake University, 18 Shilongshan Road, Hangzhou, 310024 Zhejiang Province, China;2. Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, Department of Chemistry, School of Science, Westlake University, 18 Shilongshan Road, Hangzhou, 310024 Zhejiang Province, China |
| Abstract: | Bioinformatics has become an indispensable tool for natural products research in the genomic era. One of the key challenges is to accurately convert sequence data of a biosynthetic gene cluster into chemical information such as the enzymatic function or the biosynthetic product structure. Type II polyketide synthase is the most bioinformatically well-studied class of non-modular biosynthetic machinery and represents a model system to showcase bioinformatic applications in natural products research. This review takes a bioinformatics-centered perspective and summarizes the past advances and future opportunities of bioinformatics-guided research on type II polyketide synthases. How bioinformatics has contributed to deepen the chemical understanding of type II PKSs will be discussed with the focus on enzymology, evolution, structural prediction of the biosynthetic products, genome mining, and the global analyses of their polyketide products. |
| Keywords: | bioinformatics enzymology evolutionary analysis genome mining type II polyketide synthase |