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Development of silver nanoparticles‐loaded calcium alginate beads embedded in gelatin scaffolds for use as wound dressings |
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| Authors: | Porntipa Pankongadisak Uracha Rungsardthong Ruktanonchai Pitt Supaphol Orawan Suwantong |
| Affiliation: | 1. School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai, Thailand;2. National Nanotechnology Center, Thailand Science Park, Klong Luang, Pathumthani, Thailand;3. Petroleum and Petrochemical College and Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University, Pathumwan, Bangkok, Thailand |
| Abstract: | Silver nanoparticles (AgNPs)‐loaded calcium alginate beads embedded in gelatin scaffolds were developed to sustain and maintain the release of silver (Ag+) ions over an extended time period. The UV irradiation technique was used to reduce Ag+ ions in alginate solution to AgNPs. The average sizes of AgNPs ranged between ca 20 and ca 22 nm. The AgNPs‐loaded calcium alginate beads were prepared by electrospraying of a sodium alginate solution containing AgNPs into calcium chloride (CaCl2) solution. The AgNPs‐loaded calcium alginate beads were then embedded into gelatin scaffolds. The release characteristics of Ag+ ions from both the AgNPs‐loaded calcium alginate beads and the AgNPs‐loaded calcium alginate beads embedded in gelatin scaffolds were determined in either deionized water or phosphate buffer solution at 37 °C for 7 days. Moreover, the AgNPs‐loaded calcium alginate beads embedded in gelatin scaffolds were tested for their antibacterial activity and cytotoxicity. © 2014 Society of Chemical Industry |
| Keywords: | wound dressing silver nanoparticles alginate gelatin bead drug delivery system |