Efficient Stereoselective Synthesis of Nitrocyclopropanes by the Oxidative Cyclization of Michael Adducts of Nitroolefins with Activated Methylene Compounds |
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| Authors: | Renhua Fan Yang Ye Weixun Li Lingfei Wang |
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| Abstract: | An efficient oxidative cyclopropanation of the Michael adducts of nitroolefins with activated methylene compounds by the combination of iodobenzene diacetate and tetrabutylammonium iodide is reported. Highly functionalized nitrocyclopropanes are synthesized in moderate to good yields via the Michael addition and cyclopropanation with high diastereoselectivity and enantioselectivity under mild conditions. |
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| Keywords: | cyclization cyclopropanes hypervalent compounds Michael addition oxidation stereoselectivity |
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