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An Enantioselective Synthesis of the ABD Tricycle for (−)‐Phomactin A Featuring Rawal’s Asymmetric Diels–Alder Cycloaddition |
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| Authors: | Ling‐Feng You,Richard P. Hsung,Aaron A. Bedermann,Aleksey V. Kurdyumov,Yu Tang,Grant S. Buchanan,Kevin P. Cole |
| Abstract: | An enantioselective synthesis of the ABD ring of (−)‐phomactin A is described here. The sequence features Rawal’s asymmetric Diels–Alder cycloaddition. The overall length is significantly reduced from our previous attempt. |
| Keywords: | asymmetric Diels– Alder cycloaddition chromium(II)‐salen catalyst intramolecular oxa‐[3+3] annulation phomactin A Rawal’ s 1‐amino‐3‐siloxy‐1,3‐butadiene |