| (s)-萘普生丙炔醇酯的合成 |
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| 引用本文： | 赵全义,田海燕,殷元骐,夏春谷.(s)-萘普生丙炔醇酯的合成[J].化学试剂,2004,26(4):231-232. |
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| 作者姓名： | 赵全义 田海燕 殷元骐 夏春谷 |
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| 作者单位： | 中国科学院,兰州化学物理研究所,羰基合成与选择氧化国家重点实验室,甘肃,兰州,730000;兰州医学院,药物化学教研室,甘肃,兰州,730000 |
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| 摘 要： | 以(s)—萘普生为原料，经二氯亚砜酰化为酰氯，与丙炔醇发生反应，合成萘普生丙炔醇酯，并用红外光谱、氢核磁共振谱对结构进行了表征。该方法反应条件温和，反应时问短，产率达82％。
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| 关 键 词： | (s)-萘普生 (s)-萘普生丙炔醇酯 合成 |
| 文章编号： | 0258-3283(2004)04-0231-02 |
Synthesis of(s)-naproxen propionate |
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| ZHAO Quan yi ,TIAN Hai yan ,YIN Yuan qi ,XIA Chun gu.Synthesis of(s)-naproxen propionate[J].Chemical Reagents,2004,26(4):231-232. |
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| Authors: | ZHAO Quan yi TIAN Hai yan YIN Yuan qi XIA Chun gu |
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| Affiliation: | ZHAO Quan yi 1,TIAN Hai yan 2,YIN Yuan qi 1,XIA Chun gu *1 |
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| Abstract: | s ) Naproxen propionate was synthesized by reaction of propargyl alcohol with ( s ) (2 propinyl) 2 (6 methoxy 2 naphthyl) formyl chloride which was prepared from thionyl chloride and ( s ) naproxen in the presence of triethylamine,and the resulting compound was characterized by IR and 1HNMR .The reaction condition was mild and time was short,the yield was 82%. |
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| Keywords: | s)-naproxen (s)-naproxen propionate synthesis |
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