| 活性肽RGD的液相合成 |
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| 引用本文： | 刘丽艳,崔凤侠,赵桂琴,王宏伟. 活性肽RGD的液相合成[J]. 化学试剂, 2006, 28(1): 55-56 |
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| 作者姓名： | 刘丽艳 崔凤侠 赵桂琴 王宏伟 |
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| 作者单位： | 承德医学院,化学教研室,河北,承德,067000 |
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| 摘 要： | 使用Boc-氨基酸经N,N′-二环己基碳二亚氨,在N-甲基吗啡啉存在下接肽,得到带保护基的精氨酰-甘氨酰-天冬氨酸(RGD)三肽,用CF3COOH-CF3SO3H脱保护,得到RGD肽,总产率71%。
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| 关 键 词： | RGD 氨基酸 液相合成 |
| 文章编号： | 0258-3283（2006）01-0055-02 |
| 收稿时间： | 2005-04-12 |
| 修稿时间： | 2005-04-12 |
Liquid phase synthesis of active peptide |
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| LIU Li-yan,CUI Feng-xia,ZHAO Gui-qin,WANG Hong-wei. Liquid phase synthesis of active peptide[J]. Chemical Reagents, 2006, 28(1): 55-56 |
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| Authors: | LIU Li-yan CUI Feng-xia ZHAO Gui-qin WANG Hong-wei |
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| Affiliation: | Chengde Medical College, Chengde 067000, China |
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| Abstract: | The RGD with block groups was synthesized from the boc-amino acids which were activated by DCC in N-methylmorpholine,after getting rid of the block groups with CF_3COOH and CF_3SO_3H,there resulted RGD with an overall yield of 71%. |
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| Keywords: | RGD amino acid liquid phase synthesis |
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