| 微流控芯片测定盐酸倍他司汀片中盐酸倍他司汀 |
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| 引用本文： | 李永冲,蔡自由,陈缵光. 微流控芯片测定盐酸倍他司汀片中盐酸倍他司汀[J]. 化工时刊, 2011, 25(5): 17-21. DOI: 10.3969/j.issn.1002-154X.2011.05.005 |
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| 作者姓名： | 李永冲 蔡自由 陈缵光 |
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| 作者单位： | 1. 广东食品药品职业学院,广东广州,510520
2. 中山大学药学院,广东广州,510006 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 采用微流控芯片非接触电导检测法测定片剂中的盐酸倍他司汀.采用1 mmol·L-1HAc和2 mmol·L-1NaAc(pH 4.5)为缓冲溶液,0.1 mmol·L-1SDS为添加剂,以2.40kV分离电压,10 s进样时间,盐酸倍他司汀2 min内可实现快速分离和检测.盐酸倍他司汀的线性范围为10～140μg·mL-...
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| 关 键 词： | 微流控芯片 非接触电导检测 盐酸倍他司汀 测定 |
Determination of the Betahistine Dihydrochloride in Its Tablets by Microfiuidic Chip |
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| Li Yongchong,Cai Ziyou,Chen Zuanguang. Determination of the Betahistine Dihydrochloride in Its Tablets by Microfiuidic Chip[J]. Chemical Industry Times, 2011, 25(5): 17-21. DOI: 10.3969/j.issn.1002-154X.2011.05.005 |
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| Authors: | Li Yongchong Cai Ziyou Chen Zuanguang |
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| Affiliation: | Li Yongchong Cai Ziyou Chen Zuanguang(Guangdong Food and Drug Vocational College,Guangzhou 510520; School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510089) |
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| Abstract: | The betahistine dihydrochloride in its tablets was determined by the microfluidic chip with contactless conductivity detection with 1 mmol·L-1 HAc and 2 mmol·L-1 NaAc（pH 4.5） as buffer solution,0.1 mmol·L-1 SDS as additive.The betahistine dihydrochloride was separated and detected in 2 min at 2.40 kV separation voltage and 10s injection time.The linear dependence of the concentration of the betahistine dihydrochloride ranged from 10 to 140 μg·mL-1（r=0.9999）,with the detection limit of 1.0 μg·mL-1（S/N=3）,the RSD of 1.2% and the recoveries from 98.3% to 101.7%.The method was simple,rapid and well reproducible,and it could be used in the quality control of the product. |
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| Keywords: | microfluidic chip contactless conductivity detection betahistine dihydrochloride determination |
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