| 抗哮喘药中间体7一氯喹哪啶合成技术进展 |
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| 引用本文： | 邵栋,张珍明,李树安,顾橙橙,程如意,曹新健. 抗哮喘药中间体7一氯喹哪啶合成技术进展[J]. 化工时刊, 2011, 25(6): 28-31. DOI: 10.3969/j.issn.1002-154X.2011.06.009 |
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| 作者姓名： | 邵栋 张珍明 李树安 顾橙橙 程如意 曹新健 |
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| 作者单位： | 1. 中国矿业大学化工学院,江苏徐州221116;淮海工学院,江苏连云港222005
2. 淮海工学院,江苏连云港,222005 |
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| 基金项目： | 江苏省六大人才高峰资助项目,江苏省海洋资源开发研究院基金项目,江苏省海洋资源开发研究院基金项目,江苏省连云港市科技局项目,江苏省连云港市科技局项目,淮海工学院绿色化学精品课程建设项目 |
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| 摘 要： | 7-氯喹哪啶是一种重要的药物中间体,其合成方法受到广泛关注.叙述了7-氯喹哪啶的合成方法及应用的最新进展,主要介绍了氧化剂、合成方式及原料选择对7-氯喹哪啶制备收率的影响,同时也介绍了7-氯喹哪啶和5 -氯喹哪啶的分离方法.
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| 关 键 词： | 7-氯喹哪啶 异构体分离 合成 技术进展 |
Technological Progress in Synthesis of 7 -chloroquinaldine as Intermediate of Anti - asthma Drug |
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| Shao Dong,Zhang Zhenming,Li Shuan,Gu Chengcheng,Cheng Ruyi,Cao Xinjian. Technological Progress in Synthesis of 7 -chloroquinaldine as Intermediate of Anti - asthma Drug[J]. Chemical Industry Times, 2011, 25(6): 28-31. DOI: 10.3969/j.issn.1002-154X.2011.06.009 |
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| Authors: | Shao Dong Zhang Zhenming Li Shuan Gu Chengcheng Cheng Ruyi Cao Xinjian |
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| Affiliation: | 1.School of Chemical Engineering & Technology,China University of Mining and Technology,Jiangsu Xuzhou 221116;2.School of Chemical Engineering,Huaihai Institute of Technology,Jiangsu Lianyungang 222005) |
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| Abstract: | The synthesis of 7-chloroquinaldine has emerged as attractive attention in drug intermediates.In this paper,we describes the recent development of synthesis and applications of 7-chloroquinaldine.The effect of type of the oxidants,synthetic methods and reactants selection on the yield of 7-chloroquinaldine is investigated.The separations of 5-chloroquinaldine and 7-chloroquinaldine are also introduced. |
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| Keywords: | 7-chloroquinaldine isomer separation synthesis technical progress |
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