| 1-(2-三甲基硅氧乙基)-5-巯基四氮唑的合成研究 |
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| 引用本文： | 李雪明,钱洪胜,鲁国彬,晏文武.1-(2-三甲基硅氧乙基)-5-巯基四氮唑的合成研究[J].化工时刊,2011,25(5):25-26,37. |
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| 作者姓名： | 李雪明 钱洪胜 鲁国彬 晏文武 |
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| 作者单位： | 浙江新和成股份有限公司技术中心,浙江新昌,312500 |
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| 摘 要： | 以乙醇胺为起始原料,经三甲基氯硅烷保护制得2-(三甲基硅氧基)乙胺,再经与二硫化碳反应,再与溴乙烷缩合得到N-(2-三甲基硅氧乙基)二硫代氨基甲酸乙酯、然后再与叠氮化钠成环反应合成了1-(2-三甲基硅氧乙基)-5-巯基四氮唑.用三甲基氯硅烷作为乙醇胺的羟基保护试剂,保护和脱保护具有反应条件温和、收率高等 优点,反应总收...
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| 关 键 词： | 1-(2-三甲基硅氧乙基)-5-巯基四氮唑 乙醇胺 三甲基氯硅烷 2-(三甲基硅氧基)乙胺 合成 |
Study on Synthesis of 1 - (2 - trimethyl silanyloxy - ethyl) -1H - tetrazole - 5 - thiol |
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| Li Xueming,Qian Hongsheng,Lu Guobin,Yan Wenwu.Study on Synthesis of 1 - (2 - trimethyl silanyloxy - ethyl) -1H - tetrazole - 5 - thiol[J].Chemical Industry Times,2011,25(5):25-26,37. |
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| Authors: | Li Xueming Qian Hongsheng Lu Guobin Yan Wenwu |
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| Affiliation: | Li Xueming Qian Hongsheng Lu Guobin Yan Wenwu(Technical Center of Zhejiang NHU Co.Ltd,Xinchang 312500) |
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| Abstract: | 1-（2-hydroxyethyl）-1H-tetrazole-5-thiol was synthesized from ethanolamine as the starting material,via hydroxyl protection with trimethyl chlorosilane,react with carbon bisulfide？ then condensation with bromoethane get 1-（2-trimethylsilanyloxy-ethyl）dithiocarbamic acid ethyl ester;it cyclization with sodium azide get 1-（2-trimethylsilanyloxy-ethyl）-1H-tetrazole-5-thiol.The protection and deprotection processes have advantages of mild reactive condition,high yield,the overall yield was over 85%. |
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| Keywords: | 1-（2-trimethylsilanyloxy-ethyl）-1H-tetrazole-5-thiol ethanolamine trimethyl chlorosilane 2-trimethylsilanyloxy-ethylamine synthesis |
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