外显子跳跃模式中组蛋白修饰的组合模式分析

可变剪接是基因表达调控的重要过程。组蛋白修饰参与了可变剪接，但具体调控机制尚不清楚。为了研究组蛋白修饰与可变剪接的关系，首先基于人胚肺成纤维细胞系的RNA-Seq数据，获得了该细胞系外显子跳跃模式的可变剪接数据。在此基础上，分析了外显子跳跃模式中排除和包含外显子中组蛋白修饰间的相关性。通过构建组蛋白修饰间的贝叶斯网络，推断了人胚肺成纤维细胞系外显子跳跃可变剪接事件中组蛋白修饰之间的因果关系。

Analysis of Combinatorial Pattern of Histone Modifications in Exon Skipping Event

Alternative splicing is a key process of gene expression regulation. The histone modifications are closely correlated with alternative splicing, however, its regulatory mechanisms remain unclear. In order to reveal the relationships between histone modifications and alternative splicing, by analyzing the RNA-Seq data, the exon skipping events from human embryonic lung fibroblast cell line were obtained. Subsequently, the relationships among different kinds of histone modifications were analyzed for both excluded and included exons in exon skipping event. Finally, the Bayesian network was built to deduce the casual relationships among histone modifications in exon skipping event.