| 基于光诱导介电泳的单粒子操纵技术 |
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| 引用本文： | 宋春峰,易红,倪中华.基于光诱导介电泳的单粒子操纵技术[J].机械工程学报,2010,46(7). |
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| 作者姓名： | 宋春峰 易红 倪中华 |
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| 作者单位： | 东南大学机械工程学院,南京,211189;东南大学江苏省微纳生物医疗器械设计与制造重点实验室,南京,211189 |
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| 基金项目： | 国家高技术研究发展计划(863计划,2009AA04Z310);;国家自然科学基金(50675033,30770533)资助项目 |
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| 摘 要： | 在综合分析当前生物粒子微操纵技术的基础上,设计一种基于光诱导介电泳技术的微操纵芯片,并完成芯片关键部件——光电导薄膜的加工。在准静态电场条件下,对光斑操纵模式进行建模仿真,光斑光强服从高斯分布,光斑尺寸直接影响电场平方梯度的分布,随着光斑尺寸缩小电场平方的x向梯度峰值增大,而随着高度升高电场平方的x向梯度峰值急剧减小。最后通过光诱导介电泳测试平台对单粒子操纵性能进行试验验证。试验结果表明,在去离子水中,当电压峰—峰值为20 V,频率1 MHz时,粒子受负介电泳作用而远离光斑,并且在光斑模式下直径50μm的粒子移动的最大速度可达45μm/s;而在环型虚拟电极模式下能有效控制单粒子运动方向。
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| 关 键 词： | 光诱导介电泳 微粒操纵 有限元法 |
Single Micro-particle Manipulation Based on Light-induced Dielectrophoresis |
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| SONG Chunfeng,YI Hong,NI Zhonghua.Single Micro-particle Manipulation Based on Light-induced Dielectrophoresis[J].Chinese Journal of Mechanical Engineering,2010,46(7). |
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| Authors: | SONG Chunfeng YI Hong NI Zhonghua |
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| Affiliation: | 1.School of Mechanical Engineering/a>;Southeast University/a>;Nanjing 211189/a>;2.Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments/a>;Nanjing 211189 |
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| Abstract: | Following a review of current micro-manipulation technologies of biological particles,a micro-manipulation chip based on the light-induced dielectrophoresis technology is designed.And the key component of the chip(the photoconductive film) is manufactured.Then the pattern of spot manipulation is modeled and simulated in the quasi-static electric field condition.The spot light intensity obeys Gaussian distribution.The size of spot directly influences the distribution of the gradient of the square of electric... |
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| Keywords: | Light-induced dielectrophoresis Micro-particle manipulation Finite element method |
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