促孕原位凝胶灌注液的制备及其体外释放度

以泊洛沙姆407 (P407)和188 (P188)为载体材料，采用冷溶法将促孕灌注液制成原位凝胶，考察了P407和P188浓度、羟丙基甲基纤维素浓度(HPMC)、海藻酸钠浓度及促孕灌注液对胶凝温度的影响，研究了体外溶蚀、体外释药特性. 结果表明，P407浓度为18%(w)、P188浓度为7.5%(w)、HPMC浓度为0.3%(w)时，凝胶平均胶凝温度为27.9℃, 6 h内平均体外累积溶蚀度和药物累积释放度分别为92.11%和95.42%，凝胶中的药物成分主要通过溶蚀方式释放，药物释放符合零级释药方程.

Preparation of Fertility-promoting Intrauterine Infusion in situ Gel and Its in vitro Release

Fertility-promoting intrauterine infusion in situ gel (FPG) was prepared by cold soluble method with Poloxamer 407 (P407) and Poloxamer 188 (P188). The effects of concentrations of P407, P188, hydroxy propyl methyl cellulose (HPMC) and sodium alginate on gelation temperature were studied, the gelation temperature of in situ gel before and after addition of fertility-promoting intrauterine infusion liquid and release behavior in vitro were investigated. The results showed that the average gelation temperature of FPG was 27.9℃ when the concentrations of P407, P188 and HPMC were 18%(w), 7.5%(w) and 0.3%(w). Average accumulated loss rate of gel and accumulated release rate of drug were 92.11% and 95.42% in 6 h. The drug in the gel was released by the gel erosion, and the release profiles accorded to zero order equation.