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Self-Powered Syringe Pump for Insulin Pump Therapy Based on High-Voltage Triboelectric Nanogenerator and Dielectric Elastomer Actuator |
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| Authors: | Yi Wei Wenjie Wu Yuhao Wang Xiangyu Chen Zhong Lin Wang Dan Yang |
| Affiliation: | 1. State Key Laboratory of Organic-Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029 P. R. China Engineering Research Center of Ministry of Education on Energy and Resource Saved Elastomers, Beijing University of Chemical Technology, Beijing, 100029 P. R. China Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029 P. R. China;2. Beijing Key Laboratory of Micro-nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400 P. R. China;3. School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, 30332-0245 USA;4. State Key Laboratory of Organic-Inorganic Composites, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029 P. R. China |
| Abstract: | Insulin pump therapy (IPT) is commonly utilized for treating type 1 diabetes. However, the insulin pump is generally rigid, and its prolonged use can cause discomfort to patients. Additionally, the device suffers from other drawbacks such as limited battery life. Herein, an IPT system consisting of a dielectric elastomer-based soft syringe pump (DE-SSP) and a high-voltage triboelectric nanogenerator (H-TENG) is introduced, which can achieve stable and adjustable liquid output depending on real-time blood glucose. The maximum pump volume of this IPT can reach 262.4 or 303.7 µL when powered by a DC source or H-TENG, respectively, which is generally sufficient to meet the requirements of the therapy. H-TENG possesses a sensitive self-protection mechanism that minimizes the risk of electrical damage and it can be easily fabricated or repaired and flexibly designed according to the application environment. The proposed IPT system is compatible with different placement angles and utilizes compliant electrodes with good biocompatibility that ensure its safety. It also overcomes common issues including rigidness, relatively fixed bolus delivery options, and short battery life associated with traditional insulin pumps. This study not only demonstrates a combination of H-TENG and DE-based actuators but also opens new avenues for microelectromechanical systems micropumps. |
| Keywords: | dielectric elastomers insulin pump therapy soft pumps triboelectric nanogenerators |