| ~(60)Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究 |
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| 引用本文： | 殷建林,苏燎原,刘克良. ~(60)Co-γ线照射后小鼠T、B淋巴细胞DNA合成、单链断裂、修复能力的比较研究[J]. 辐射研究与辐射工艺学报, 1988, 0(1) |
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| 作者姓名： | 殷建林 苏燎原 刘克良 |
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| 作者单位： | 苏州医学院 苏州(殷建林，苏燎原)，苏州医学院 苏州(刘克良) |
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| 基金项目： | 国家自然科学基金会资助的课题 |
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| 摘 要： | 本文采用滤膜法和碱洗脱法比较研究了γ线照射后T、B淋巴细胞DNA合成、ssb(单链断裂)及修复能力。B淋巴细胞DNA合成明显低于T淋巴细胞;虽两种细胞产生DNA ssb没有差别,但其修复能力,T淋巴细胞高于B淋巴细胞。说明在分子水平上,B淋巴细胞辐射敏感性高于T淋巴细胞;DNA ssb的修复能力与DNA合成可能存在一定的联系。
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| 关 键 词： | DNA合成 DNA ssb DNA修复 T、B淋巴细胞 辐射敏感性 碱洗脱法 |
COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ~(60)Co GAMMA-RAYS IRRADIATION |
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| Yin Jianlin,Su Liaoyuan,Liu Keliand Division of Radiological Injury,Suzhou Medical College Suzhou. COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ~(60)Co GAMMA-RAYS IRRADIATION[J]. Journal of Radiation Research and Radiation Processing, 1988, 0(1) |
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| Authors: | Yin Jianlin Su Liaoyuan Liu Keliand Division of Radiological Injury Suzhou Medical College Suzhou |
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| Abstract: | The synthesis of DNA in T, B lymphocytes was investigated by thedetermination of ~3H-TdR incorporation after Gamma-irradiation. The DNA ssb (singlestrand breaks) and repair in lymphocytes were measured by alkaline elution. The DNAsynthesis in B lymphocytes was much lower than that in T lymphocytes. No signifigantdifference in DNA ssb was found between T and B lymphocytes, but a less efficientprocess of repair was observed in B lymphoeytes, So it was conceived that B lymphocy-tes were more sensitive to Gamma-irradiation than T lymphocytes and DNA synthesismight be related with the repair of DNA ssb. |
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