对甲苯磺酸铜催化合成香兰素1,2-丙二醇缩醛的研究

以香兰素和1,2-丙二醇为原料,对甲苯磺酸铜为催化剂,苯为带水剂,合成了香兰素1,2-丙二醇缩醛。考察了原料摩尔比、催化剂用量和反应时间等因素对产品收率的影响。结果表明:对甲苯磺酸铜具有良好的催化活性,且可重复使用3次。最佳工艺条件为:香兰素15.2 g(0.1 mol),n(香兰素):n(1,2-丙二醇)=1∶1.60,对甲苯磺酸铜0.9 g,苯25 mL,反应时间2.5 h条件下,产品收率达到87%以上。

Synthesis of Vanillin 1,2-Propylene Glycol Acetal with Copper p-Toluene Sulfonate Catalyst

Vanillin 1,2-propylene glycol acetal was synthesized from vanillin and 1,2-propylene glycol using copper p-toluene sulfonate as catalyst and benzene as water stripping agent.The effects of molar ratio of the reactants,catalyst dosage and reaction time on yield were investigated.Copper p-toluene sulfonate showed high catalytic activity,and the catalyst was reused for 3 times.The preferential conditions are: based on 15.2 g(0.1 mol) of vanillin,the molar ratio of vanillin to 1,2-propylene glycol is 1∶1.60;the dosage of catalyst is 0.9g,the amount of benzene as water stripping agent is 25 mL;the reaction time is 2.5 h.The yield can achieved 87%.