家蚕丝蛋白纳米颗粒的研究进展

家蚕丝蛋白由于具有良好的物理、化学和生物学性能,以及其无毒、无害、无免疫原性,与人体有较好的组织相容性等特性,近年来在材料学、化妆护肤品、生物医学等领域有着广阔的应用前景。文中介绍家蚕丝素与丝胶蛋白纳米颗粒的制备方法及其应用,包括相分离法、乳化-溶剂蒸发法、盐析法、电喷法、电场调控法、自组装法、接枝共聚法和纳米混悬法,并指出了现研究阶段存在的问题。

Research and development of silk protein nanoparticles

Silk protein has great potential applications in material science,cosmetics,biomedicine and other fields due to its excellent physical,chemical and biological properties,as well as its characteristics of avirulence,innocuity,non-immunogenicity and good histocompatibility for human body.This article details the preparations of silk fibroin and sericin nanoparticles,including phase separation method,emulsion-solvent evaporation method,salting out method,electrospray method,electrical control method,self-assembling method,graft copolymerization method and nanosuspension technology.Existing problems in resent research are pointed out.