Solubility of Ketoconazole in Ethanol + Water Mixtures at Various Temperatures |
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Authors: | Nastaran Hashemzadeh |
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Affiliation: | Faculty of Pharmacy, Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran |
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Abstract: | Ketoconazole is an important drug with low water solubility. Its low aqueous solubility could be increased using various methods such as by the addition of a pharmaceutical cosolvent. The solubility of ketoconazole in ethanol + water mixtures at 293.2, 298.2, 303.2, and 308.2 K were determined, and the results showed that the addition of ethanol increased the solubility and the maximum value was obtained at 80% of ethanol. The generated data were mathematically represented using the Jouyban–Acree model within an acceptable accuracy. |
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Keywords: | Ethanol + water mixtures Jouyban–Acree model Ketoconazole Solubility prediction |
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