MOVING PORT CHROMATOGRAPHY: A METHOD OF IMPROVING PREPARATIVE CHROMATOGRAPHY

A computer study of conventional, moving feed, moving withdrawal and moving port chromatography systems was conducted. The linear ternary system of naphthalene, anthracene, and pyrene in 2-propanol with Polyclar AT as the stationary phase was studied. Moving withdrawal ports in conjunction with moving feed chromatography (moving port system) resulted in an average increased purity of 22% and an average increased throughput of 120% compared to conventional chromatography. Moving feed chromatography increased purity by 22% and throughput by 33%, and moving withdrawal chromatography increased throughput by 39% over the conventional case with no change in purity. A local equilibrium model with zone spreading was also developed and use to determine reasonable operating conditions for these chromatographic systems.