A GREENER SYNTHESIS TECHNOLOGY FOR LOMEFLOXACIN HYDROCHLORIDE |
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| Authors: | Shuiming Cheng Yuanxin Wu Rui Chen Ziniu Yu Xinya Zhang |
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| Affiliation: | 1. Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology , Wuhan, China;2. State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University , Wuhan, China;3. School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, China |
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| Abstract: | Lomefloxacin ethyl ester was prepared from 2,3,4-trifluoroaniline in ionic liquid in a one-pot procedure by condensation with EMME (ethoxymethylenemalonic diethyl ester), cyclization, ethylation, and condensation with 2-methyl piperazine. After its hydrolysis and salifying with hydrochloric acid, lomefloxacin hydrochloride was obtained with an overall yield of 58.4%. Compared with current lomefloxacin hydrochloride synthesis technology, this approach simplified its synthesis procedures, shortened its synthesis time, and eliminated the usage of volatile organic solvents. |
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| Keywords: | Ionic liquid Lomefloxacin hydrochloride Synthesis |
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