| 5-硝基水杨酸的合成新工艺研究 |
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| 引用本文： | 付中林,伍杰.5-硝基水杨酸的合成新工艺研究[J].化学与生物工程,2005,22(7):46-47. |
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| 作者姓名： | 付中林 伍杰 |
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| 作者单位： | 武汉化工学院,湖北,武汉,430073;湖北科兴医药化工股份有限公司,湖北,襄樊,441021 |
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| 摘 要： | 以2-氯-5-硝基苯甲酸为原料,在碱性条件下经催化水解、酸化合成5-硝基水杨酸,考察了催化剂K2CO3/KOH的质量比、原料配比、反应温度、反应时间对产率的影响,获得了最佳的反应条件:原料配比(质量比)为K2CO3/KOH∶2-氯-5-硝基苯甲酸=80∶100,反应温度为130~140℃,反应时间为15h。在最佳反应条件下,产品收率可达95%以上。
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| 关 键 词： | 5-硝基水杨酸 2-氯-5-硝基苯甲酸 合成 工艺 |
| 文章编号： | 1672-5425(2005)07-0046-02 |
| 修稿时间： | 2005年3月4日 |
Study on a Novel Technique for the Synthesis of 5-Nitrosalicylic Acid |
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| FU Zhong-lin,WU Jie.Study on a Novel Technique for the Synthesis of 5-Nitrosalicylic Acid[J].Chemistry & Bioengineering,2005,22(7):46-47. |
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| Authors: | FU Zhong-lin WU Jie |
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| Affiliation: | FU Zhong-lin~ |
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| Abstract: | Using 2-chloro-5-nitrobenzoic acid as a raw material,5-nitrosalicylic acid was prepared by base-catalyzed hydrolysis and acidification. The effects of concentration of K_(2)CO_(3)/KOH,mass ratio of K_(2)CO_(3)/KOH and 2-chloro-5-nitrobenzoic acid, reaction temperature and time on the yield of 5-nitrosalicylic acid were investigated, and the optimal conditions were acquired.Under the optimal reaction conditions,which mass ratio of K_(2)CO_(3)/KOH and 2-chloro-5-nitrobenzoic acid was 80100,reaction temperature was 130~140 and reaction time was 15 h, the yield of 5-nitrosalicylic acid could be over 95%. |
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| Keywords: | 5-nitrosalicylic acid 2-chloro-5-nitrobenzoic acid synthesis technique |
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