Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations |
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| Authors: | Miyazaki Shozo Endo Kumiko Kawasaki Naoko Kubo Wataru Watanabe Hideki Attwood David |
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| Affiliation: |
a Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari-Tohbetsu, Hokkaido, Japan
b School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, UK |
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| Abstract: | The purpose of this study was to evaluate the potential of a xyloglucan formulation with in situ gelling properties for the oral sustained delivery of paracetamol. Gelation of dilute aqueous solutions of the polysaccharide xyloglucan occurred in rabbit and rat stomachs as the orally administered chilled solutions attained body temperature. In vitro studies demonstrated diffusion-controlled release of paracetamol from the gels over a period of 6 hr. The bioavailabilities of paracetamol from the xyloglucan gels formed in situ in the stomachs of rabbits after oral administration of the liquid formulations were similar to that of a commercially available suspension containing an identical dose of paracetamol. |
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| Keywords: | Xyloglucan gels Oral drug delivery In situ gelation Sustained release Paracetamol |
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