Age Related Osteoporosis: Targeting Cellular Senescence |
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Authors: | Ursula Fger-Samwald Katharina Kerschan-Schindl Maria Butylina Peter Pietschmann |
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Affiliation: | 1.Medical Science and Human Medicine Study Programme, Karl Landsteiner University of Health Sciences, 3500 Krems an der Donau, Austria;2.Department of Physical Medicine and Rehabilitation, Medical University of Vienna, 1090 Vienna, Austria;3.Department of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria; (M.B.); (P.P.) |
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Abstract: | Age-related chronic diseases are an enormous burden to modern societies worldwide. Among these, osteoporosis, a condition that predisposes individuals to an increased risk of fractures, substantially contributes to increased mortality and health-care costs in elderly. It is now well accepted that advanced chronical age is one of the main risk factors for chronical diseases. Hence, targeting fundamental aging mechanisms such as senescence has become a promising option in the treatment of these diseases. Moreover, for osteoporosis, the main pathophysiological concepts arise from menopause causing estrogen deficiency, and from aging. Here, we focus on recent advances in the understanding of senescence-related mechanisms contributing to age-related bone loss. Furthermore, treatment options for senile osteoporosis targeting senescent cells are reviewed. |
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Keywords: | cellular senescence age-related osteoporosis osteoporosis therapy |
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