Dysregulation of mTOR Signaling after Brain Ischemia |
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| Authors: | Mario Villa-Gonzá lez,Gerardo Martí n-Ló pez,Marí a José Pé rez-Á lvarez |
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| Affiliation: | 1.Departamento de Biología (Fisiología Animal), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049 Madrid, Spain; (M.V.-G.); (G.M.-L.);2.Centro de Biología Molecular “Severo Ochoa” (CBMSO), Universidad Autónoma de Madrid/CSIC, 28049 Madrid, Spain |
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| Abstract: | In this review, we provide recent data on the role of mTOR kinase in the brain under physiological conditions and after damage, with a particular focus on cerebral ischemia. We cover the upstream and downstream pathways that regulate the activation state of mTOR complexes. Furthermore, we summarize recent advances in our understanding of mTORC1 and mTORC2 status in ischemia–hypoxia at tissue and cellular levels and analyze the existing evidence related to two types of neural cells, namely glia and neurons. Finally, we discuss the potential use of mTORC1 and mTORC2 as therapeutic targets after stroke. |
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| Keywords: | mTOR mTORC1 mTORC2 MCAo brain ischemia glia microglia astrocytes oligodendrocytes neuron |
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